The lack of apoptosis is further confirmed by electron microscopic analysis of E6.5 embryos, in which we did not detect any morphological alterations associated with apoptotic cell death, such as condensed and fragmented nuclear chromatin or interrupted nuclear envelope, for either of the genotypes (see below the ultra-structural analyses part).
Similar morphological alterations associated with pyknosis and karyorrhexis (nuclear fragmentation) were observed in cancer cells treated with cytotoxic proteins isolated from the various plant sources [ 27, 28].
Cells rounded together and were characterized by substantial cell-surface blebbing, typical features of epithelial cancers undergoing morphological alterations associated with apoptosis [ 5].
The expression of such morphological alterations is associated with genomic instability.
Such dramatic morphological alterations are associated with considerable mechanical stress.
Morphological alterations are associated with 35S AtCTF7∆B and atctf7-1 plantransformedmed with CTF7pro AtCTF7∆B.
The morphological alterations were associated with proteinuria starting in mouse early adulthood (∼50 days after birth).
The device can collect multimodal data in autofluorescence or reflectance modes, in order to measure different morphological and biochemical alterations associated with cancer progression.
In this and other models that depend on an initial period of status epilepticus, the morphological and functional alterations associated with the substantial neuronal loss have been implicated in the establishment of the chronic epileptic focus.
Although an increased phosphorylation of the S6 ribosomal protein has been observed, and it is known to correlate with an enhanced protein synthesis, the kind of relation between EP3 overexpression and morphological and metabolic alterations associated with the cardiomyopathic properties of these hearts has not been characterised.
Opposed to our initial hypothesis, the severe morphological and presumably functional barrier alterations associated with AD [13 16, 18, 31] did not increase the penetration of CMS past the stratum corneum.
