The radiation dose used in these experiments kills approximately 99.9% of the cells, but at these relatively early time points, out to 3 days, the cells were essentially 100% viable, although enlarged, and there were no morphological abnormalities observed by phase contrast (ie, the cells did not look apoptotic morphologically).
The morphometric evidence in favor of the dysconnectivity model of SZ includes subtle but wide-spread morphological abnormalities observed in postmortem studies.
Additionally, these strains may model the dosage-dependent nature of SMA [1], [2] as the developmental arrest associated with these animals correlates with the extent of morphological abnormalities observed at the NMJ.
This is consistent with morphological abnormalities observed in pha-1 mutant embryos and larvae.
The morphological abnormalities observed in Munc18-1 null, but not Munc13-1/2 Munc13-1/2l, growth cones may also relate to the previously observedoublects of PLA (phospholipase A2) anullA (arachidonic acid) in growth cones.
On the basis of the lens fiber cell morphological abnormalities observed in the transgenic mice, we reasoned that the dnBrg1 expression could affect lens fiber cell ultrastructure and contacts between individual lens fiber cells.
Of the morphological abnormalities observed, the most prevalent in the extended semen were proximal cytoplasmic droplets (7 27%), pear-shaped heads (3.6 7%), heads with narrow bases (1.5 5%) and narrow heads (1 3%).
However, ERGs in the Adam9−/− mice appear less severely disturbed than those of β 5 −/− mice, whereas β 5 −/− mice lack the morphological abnormalities observed at the RPE-POS junction in Adam9 −/− mice.
However, no obvious morphological abnormality was observed in the liver when biochemical alterations such as lipid peroxidation were not detectable, suggesting a redundant or less important physiological role for MnSOD in the liver than previously thought.
H&E stain showed that no morphological abnormality was observed in sham control rats.
