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CMs show distinctive morphological abnormalities such as rods, an abnormal number of central nuclei or (central or multiple) cores.
Additional morphological abnormalities such as abnormalities of the isthmus are further detailed in Table 1 for each stage.
Morphological abnormalities such as unusually long spines, shorter spines, and reduced number of spines have been documented in the cortex of DS fetuses and newborns [2], [3].
In seedlings, both methods of HSP90 reduction resulted in similar morphological abnormalities, such as altered leaf shape, organ number, and pigment accumulation.
When sub-analyzing the current kinetics and amplitudes with respect to morphological abnormalities, such as branching and splitting, we found no correlation between split fibres in older mdx mice and either only small or larger amplitudes in these fibres.
In a subpopulation of parasites, morphological abnormalities such as condensed chromatin clumped to protrusions in nuclear lobes (Fig. 6D and E), mitochondrial swelling with lack of kinetoplast organization (Fig. 6C) and vacuole-like structures, formed by mitochondrial or endoplasmic-reticulum membranes containing cytoplasmic material (Fig. 6C), were observed.
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This was evidently not dependent on morphological abnormality, such as axonal swellings.
As shown in Figure 1E by electron microscopy, exposure to IR induced morphological abnormalities in PBMCs, such as nucleolus fragmentation and the presence of apoptotic bodies.
Such morphological abnormalities may lead to future development of microvascular complications among T1D pediatric patients with poor glycemic control.
This is particularly important when considering the time course of the disease, with initial phases of vast degeneration and ongoing degeneration/regeneration cycles, which can even take place in the same fibre simultaneously [55] and give rise to morphological abnormalities in aged fibres such as branching or splitting [10], [56].
Previous neuroimaging studies have revealed widespread morphological abnormalities associated with AVHs, such as gray matter loss in the frontal [ 4, 5], insular [ 6], and anterior/posterior cingulate [ 7, 8] cortices.
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