The morphological abnormalities we found can also be a sign of some degree of subfertility and could be further characterized.
For cases with few morphological abnormalities, we found that accurate cell identification and classification were the principle requirements for success.
No morphological abnormalities were found in the olfactory epithelia or olfactory bulbs of the Chd7 Whi /+ embryos at E16.5 (Supplementary Figure 1).
In a study by Scaroni et al. adrenal morphological abnormalities were found in 28.7% of acromegalic patients (n=94), among them nine cases with unilateral adenoma and the rest with uni- or bilateral hyperplasia.
The unusual morphological abnormality we found (long-side folding of sperm heads) had not been reported and the mechanism underneath became difficult to explain.
Despite the extensive Cre-mediated recombination in the mammary gland of Wcre females (Fig. 1), we did not find morphological abnormalities in virgin, pregnant or parous Wcre Cdh1 F/F mice (Fig. 2A, left panels).
However, upon examination of random sections through each of these tissues in each CK19CreERT; LSL-KrasG12D mouse at 4 6 months post-tamoxifen, we failed to find any morphological abnormalities in liver, kidney or small intestine.
Occludin knockout mice have been found to develop morphological abnormalities in various organs (Saitou et al., 2000).
These results potentially conflict with our previous findings showing that morphological abnormalities, including wing colour pattern aberrations, found in the F1 generation were heritable by the F2 generation [ 7- 9].
When sub-analyzing the current kinetics and amplitudes with respect to morphological abnormalities, such as branching and splitting, we found no correlation between split fibres in older mdx mice and either only small or larger amplitudes in these fibres.
