However, most methods rely on diffuse light transport, which can be insufficient to resolve important morphologic transformations that have dimensions comparable to the optical wavelength [ 35], because its spatial resolution is limited by light scattering in tissues [ 36].
Distributions of the scattering amplitude and scattering slope showed less variance than functional absorption parameters, like hemoglobin concentration and oxygenation status, because the morphologic transformations that determine light scattering occur on submicron and even subnanometer length scales [ 50, 51].
Such stepwise morphologic transformations in the "classic" ETANTR appearance due to disease progression allow one to suppose that the three "histological variants" of ETMR may constitute either "polar ends" of a morphologic spectrum or varying differentiation stages of a single tumor entity rather than separate nosologic categories.
Our results revealed that ginsenoside Rg1 obviously blocked morphologic transformation in NRK-52E induced by TGF-β1.
Examining the role of miR-128 in EMT and tumor cell invasion and motility, Qian et al. [140] demonstrated that overexpression of miR-128 suppressed the morphologic transformation associated with EMT, retarded wound closing, and reduced cell migration and invasion in MDA-MB-231 cells.
Aggressivity depends on the persistence of HR HPV more than on progressive morphologic transformation.
It indicates that the transformation from anatase to sodium tri-titanate nanotubes includes the following three steps: (1) aggregation of spherical anatase particles (0 1 h), (2) morphologic transformation to titanate nanosheets with fewer visible anatase crystal arrays (1 3 h), and (3) crimping of tri-titanate nanosheets and a final generation of TNTs (3 6 h).
We performed this analysis in rat epithelial cells first, because they are highly sensitive to TRKB-mediated oncogenic transformation, as marked by an EMT-like morphologic transformation, anoikis resistance and metastatic tumor formation in nude mice [24] [26].
Consistent with our previous observations [24] [26], for cells expressing wild-type TRKB+BDNF this resulted in EMT-like morphologic transformation (Figure 3B, Figure S1E), downregulation of E-cadherin (Figure 3C and Figure S1F) and anoikis suppression (Figure 3D, Figure S1G).
Microglia in the SN displayed similar acute morphologic transformation from resting to activated states in both types of mice [see Supplemental Material, Figure 1B D (doi:10.1289/ehp.1003013)].
Interestingly, besides inhibiting morphologic transformation of premalignant breast cells, reduction mammoplasty-derived fibroblasts were also found to have the ability to suppress estrogen responsiveness of premalignant breast cells.
