Sentence examples for morphologic transformation in from inspiring English sources

Our results revealed that ginsenoside Rg1 obviously blocked morphologic transformation in NRK-52E induced by TGF-β1.

However, each of these three compounds can cause DNA damage and cytogenetic alterations in mammalian cells (Dopp et al. 2004; Kligerman et al. 2003), inhibit nucleotide excision repair (Schwerdtle et al. 2003), and induce morphologic transformation in Syrian hamster embryo cells (Lee et al. 1985; Ochi et al. 2004).

In a mammary epithelial background, activated HRAS alone induced EMT; in contrast, DIAPH3 silencing in the context of activated HRAS resulted in an amoeboid transition consisting of a dramatic morphologic transformation in basement membrane cultures and high invasive potential (Fig 2).

Such stepwise morphologic transformations in the "classic" ETANTR appearance due to disease progression allow one to suppose that the three "histological variants" of ETMR may constitute either "polar ends" of a morphologic spectrum or varying differentiation stages of a single tumor entity rather than separate nosologic categories.

Microglia in the SN displayed similar acute morphologic transformation from resting to activated states in both types of mice [see Supplemental Material, Figure 1B D (doi:10.1289/ehp.1003013)].

Consistent with our previous observations [24] [26], for cells expressing wild-type TRKB+BDNF this resulted in EMT-like morphologic transformation (Figure 3B, Figure S1E), downregulation of E-cadherin (Figure 3C and Figure S1F) and anoikis suppression (Figure 3D, Figure S1G).

We performed this analysis in rat epithelial cells first, because they are highly sensitive to TRKB-mediated oncogenic transformation, as marked by an EMT-like morphologic transformation, anoikis resistance and metastatic tumor formation in nude mice [24] [26].

Examining the role of miR-128 in EMT and tumor cell invasion and motility, Qian et al. [140] demonstrated that overexpression of miR-128 suppressed the morphologic transformation associated with EMT, retarded wound closing, and reduced cell migration and invasion in MDA-MB-231 cells.

Aggressivity depends on the persistence of HR HPV more than on progressive morphologic transformation.

Pathological changes in the brain or spinal cord cause rapid microglial migration to the affected area where they undergo phenotypic and morphologic transformation.

Interestingly, besides inhibiting morphologic transformation of premalignant breast cells, reduction mammoplasty-derived fibroblasts were also found to have the ability to suppress estrogen responsiveness of premalignant breast cells.