Exact(11)
Aggressivity depends on the persistence of HR HPV more than on progressive morphologic transformation.
Our results revealed that ginsenoside Rg1 obviously blocked morphologic transformation in NRK-52E induced by TGF-β1.
It indicates that the transformation from anatase to sodium tri-titanate nanotubes includes the following three steps: (1) aggregation of spherical anatase particles (0 1 h), (2) morphologic transformation to titanate nanosheets with fewer visible anatase crystal arrays (1 3 h), and (3) crimping of tri-titanate nanosheets and a final generation of TNTs (3 6 h).
We performed this analysis in rat epithelial cells first, because they are highly sensitive to TRKB-mediated oncogenic transformation, as marked by an EMT-like morphologic transformation, anoikis resistance and metastatic tumor formation in nude mice [24] [26].
Consistent with our previous observations [24] [26], for cells expressing wild-type TRKB+BDNF this resulted in EMT-like morphologic transformation (Figure 3B, Figure S1E), downregulation of E-cadherin (Figure 3C and Figure S1F) and anoikis suppression (Figure 3D, Figure S1G).
Interestingly, besides inhibiting morphologic transformation of premalignant breast cells, reduction mammoplasty-derived fibroblasts were also found to have the ability to suppress estrogen responsiveness of premalignant breast cells.
Similar(49)
However, most methods rely on diffuse light transport, which can be insufficient to resolve important morphologic transformations that have dimensions comparable to the optical wavelength [ 35], because its spatial resolution is limited by light scattering in tissues [ 36].
Distributions of the scattering amplitude and scattering slope showed less variance than functional absorption parameters, like hemoglobin concentration and oxygenation status, because the morphologic transformations that determine light scattering occur on submicron and even subnanometer length scales [ 50, 51].
Such stepwise morphologic transformations in the "classic" ETANTR appearance due to disease progression allow one to suppose that the three "histological variants" of ETMR may constitute either "polar ends" of a morphologic spectrum or varying differentiation stages of a single tumor entity rather than separate nosologic categories.
In addition, because DEHP also induces biological effects that occur independently of peroxisome proliferation (e.g., morphologic cell transformation and decreased levels of gap junction intercellular communication), it is possible that some of these responses also contribute to the carcinogenicity of this chemical.
Sections of nonmalignant brain tissue (preterm and older paediatric) obtained at autopsy and fixed within 24 h of death, as well as from a surgical case of a CP cyst from a patient without morphologic evidence of neoplastic transformation, were also analysed for Survivin expression.
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