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The five year cumulative survival rate for patients stratified by NET morphologic subtypes was significantly higher in TC and AC [87.6% and 62.5%, respectively] than in the LCNECs and SCLC [24.2% and 20.7%, respectively].
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The most common morphologic subtypes are papillary carcinoma (38%), mucinous adenocarcinoma (34%), conventional adenocarcinoma (0.11%), NOS (0.07%) and papilotubular carcinoma (0.07%).
mRNA expression was heterogeneous in the breast tumour tissue, and no morphologic subtype was predominant in the high or low categories.
The SNP associations by tumor morphologic subtype were evaluated by comparing ductal tumors to all others and, in a separate analysis, lobular tumors to all others.
Distinguishing between the subtypes is usually made by morphologic assessment, which is not always accurate.
Current data indicate that each of these histological subtypes is associated with distinct morphologic and molecular genetic alterations (Bell, 2005).
Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed.
To the best of our knowledge, the association between these epitopes and the new morphologic subtypes has not been hitherto investigated in this population.
Two other subtypes were noted.
How many subtypes are there in all?
The two subtypes are genetically distinct.
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