The morphologic subtypes of AML also include rare types not included in the FAB system, such as acute basophilic leukemia, which was proposed as a ninth subtype, M8, in 1999.
(6) Tumor subtypes: module alteration patterns, and possibly module structure is likely to differ between different tumor subtypes, such as the EGFR, PDFGRA and NF1 subtypes of GBM.
Nevertheless, such genetic changes were less investigated in adenoma stage and a comprehensive survey of oncogenic mutations in EGFR signaling pathway according to different morphologic subtypes has not been performed.
This further confirms the diversity of both morphologic subtypes not only on the basis of morphologic aspects but also on the clinical outcome that seems better in the M3 subtype than in the M3v subtype (Haferlach et al, 2005b).
NHL is a heterogeneous condition and comprises several different morphologic subtypes with distinct clinical behaviors and outcomes.
Although overrepresented as a group, the soft tissue sarcomas observed in this study were heterogeneous in subtype, with four different morphologic subtypes represented.
The main purpose of the study was to assess EGFR expression by immunohistochemistry and correlate with the morphologic subtypes according to the new adenocarcinoma classification.
Variation of reported percentages is most likely based on selection of cases (benign and malignant as well as morphologic subtypes), technical factors and subjective interpretation.
Several previously unreported variants exhibited associations at P <10−6 in the analyses by PR status, HER2 status, TN phenotype, morphologic subtypes, histological grade and nodal involvement.
The most common morphologic subtypes are papillary carcinoma (38%), mucinous adenocarcinoma (34%), conventional adenocarcinoma (0.11%), NOS (0.07%) and papilotubular carcinoma (0.07%).
