Sentence examples for morphologic shift from inspiring English sources

Tumor epithelial cells undergo a morphologic shift through the process of EMT with characteristic loss of cell polarity, conferring invasive and metastatic properties during cancer progression.

Such a morphologic shift, however, does not appear to stem from the inhibition of caspases, because neither the catalytic functions nor the activation of these proteases require ATP (which should not be confounded with deoxy-ATP, see below).

A similar morphologic shift has been observed in cells succumbing to tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A, best known as tumor necrosis factor receptor 1, TNFR1) ligation in the presence of geldanamycin and in the absence of RIPK1 or one of its downstream targets, that is, receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL).

In both cases, modulations in the Shh pathway were related to eco-morphologic shifts and the phenotype change had a clear functional significance [ 71, 72].

EIT measurements at a juxta-diaphragmatic level implicate a potential shift of morphologic structures into the EIT sensitivity region affecting data interpretation.

Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates.

First, at very low CD4+ T-cell counts, the morphologic presentation of cHL may shift to an appearance more similar to non-Hodgkin lymphoma (in which there are fewer CD4+ T cells in the tumor microenvironment), resulting in a diagnostic misclassification.

The systematic approach with defined statistical criteria means that this method can theoretically be used not only to identify candidates of the drug targets but also to assess the effects of any condition that induces morphologic changes (e.g., genetic mutations, nutritional starvation, and temperature shifts, among others).

However, we note that the taxonomy of the diverse Thomasomys, for which we also infer a branch-specific shift in diversification rates using MEDUSA, is mostly based on morphologic evidence [ 75].

Our research focus has shifted from detection of JSN on radiography to visualization of morphologic and pre-morphologic changes of cartilage by using conventional as well as sophisticated MRI techniques.

Recent literature suggests, however, that a shift toward a TH1 cytokine profile during pregnancy may increase the risk of fetal morphologic defects.