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Abundant altered morphologic phenotypes in colonies, blastospores and hyphae formations were observed in the arbitrary insertional mutants of N. rileyi, which made it possible to study the relationships between the functions and the interrupted genes over the whole genome.
Among the three ribonucleotide reductase mutants in the mutant panel, the rnr1 (R = 0.592) and rnr4 (R = 0.836) mutants were identified based on similar morphologic phenotypes in these mutants and hydroxyurea-treated wild-type yeast (Figure 2B and C, Table 2).
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These findings reinforce the caution that a loss-of-function mutant that displays a strong morphologic phenotype in one cell type but no morphologic phenotype in other cell types does not preclude that the mutant is also partially defective in other cell types, although not manifested at a morphologic level.
In the Drosophila and mouse models of FXS, GABAergic compounds have been shown to reverse many of the related behavioral and morphologic phenotypes associated with FXS in these systems, 91, 92 suggesting GABA(A) receptors are sensitive to GABAergic drugs and that stimulation of GABA receptors could be a viable treatment for FXS.
The current version of our high-content image-profiling system is limited to nonessential genes because morphologic phenotypes of mutants carrying deletions in essential genes are not available.
This radiologic separation of disease components may be a next step in further defining morphologic phenotypes within COPD.
The importance of the HGF pathway was further documented in our system by blocking HGF signaling with an antibody, resulting in reversal of expression and morphologic phenotypes.
Gene signatures corresponding to these morphologic phenotypes were shown to accurately predict clinical outcome in independent datasets of human breast cancers [ 44].
Fifty yeast morphologic phenotypes were mapped to genetic loci that overlapped with the eQTLs in 19 modules.
The 'MINO' (mammary intraepithelial neoplasia outgrowth) mouse model of ductal carcinoma in situ (DCIS) consists of six lines with distinct morphologic phenotypes and behavior, each meeting experimentally defined criteria for 'precancer'precancer
Among the set of ATAA samples, we studied specimens from patients displaying bicuspid (BAV) and tricuspid aortic valve (TAV) morphologic phenotypes.
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