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Staying with a biological viewpoint, the histological diversity of HELUs can be seen as morphologic manifestations of variable differentiation and/or acquired genetic alterations in the cells.
In summary, the morphologic manifestations of cell death can easily be altered in the absence of bona fide cytoprotection, casting doubts on the actual value of morphology-based classifications of cell death.
In this case, it is quite probable that VEGF tumour concentration will correlate with morphologic manifestations of tumour angiogenesis and that both these factors will be implicated in the disease prognosis.
Possibly, this reflects the ability of PARP1, an NAD+-dependent enzyme initially characterized for its role in DNA repair and the DNA damage response, to provoke an abrupt decline in intracellular ATP levels (secondary to NAD+ depletion), hence blocking various morphologic manifestations of apoptosis.
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CT and magnetic resonance (MR) imaging directly demonstrate the typical morphologic manifestation of constrictive pericarditis which is generalized pericardial thickening and pericardial calcifications [1].
Apoptosis, the morphologic manifestation of programmed cell death, is associated with normal central nervous system (CNS) development [ 8].
Based on the foregoing observations, it is reasonable to conclude that at least some flat epithelial atypias are probably neoplastic proliferations that may well represent either a precursor of or the earliest morphologic manifestation of low-grade DCIS, as well as being a precursor to invasive carcinoma, particularly tubular carcinoma.
Importantly, a growing body of evidence indicates that the pharmacologic or genetic inhibition of the processes that are commonly considered as essential for cell death execution often does not avoid the demise of mammalian cells, but rather alters its kinetics and biochemical (and morphologic) manifestations.
Molecular methods, in contrast, provide objective biomarkers for diagnoses, may permit disease detection prior to morphologic manifestations and, most importantly, can provide patient stratifications for more effective therapy.
These observations indicate that, similar to their morphologic counterparts, the biochemical manifestations of cell death can be altered in the absence of efficient cytoprotection.
When the disease involves the peripheral blood and bone marrow, it is called CLL, while when lymph nodes or other tissues are infiltrated by cells with identical morphologic and immunophenotypic features to CLL, and yet leukemic manifestations of the disease are absent, it is called small lymphocytic lymphoma.
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