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This chapter provides background for mammary gland evaluations including details of biology and development, species and sex comparisons, hazard identification and study design approaches, morphologic evaluation and diagnosis, and mechanisms of mammary toxicity and carcinogenicity.
This chapter provides details about mammary gland biology, development, species comparisons, approaches to hazard identification and study design, morphologic evaluation and diagnosis, and mechanisms of mammary toxicity and carcinogenicity in order to provide necessary background for thorough and appropriate evaluations.
Differentiation was assessed by colony-forming cell (CFC) assays combined with morphologic evaluation and flow cytometric immunophenotyping.
In the hepatic model, total liver weight was recorded and compared between the treated and the control groups of mice before formalin-fixation for morphologic evaluation and immunohistochemistry. Formalin-fixed, paraffin-embedded sections of colon cancer metastatic tissues were stained with haematoxylin/eosin and alcian blue for morphologic evaluation.
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Standard morphologic evaluation of FNA and biliary brushing specimens carries a high false negative rate and at times lacks diagnoses of pancreatic masses and their associated biliary strictures [ 4- 7, 34].
To verify whether the morphologic evaluation of zygotes and embryos derived from thawed oocytes could provide some relevant information regarding their developmental performance.
Measurement of central corneal thickness (CCT) and endothelial cell parameters is important when undertaking a functional and morphologic evaluation of the cornea for diagnostic purposes or before various surgical interventions.
Differential leukocyte count and morphologic evaluation of cells were performed in blood smears stained with panoptic 12 under optic microscopy.
Although MRIs allow direct visualization and morphologic evaluation of joint tissues not otherwise discernible on x-ray, their specific pathologies need to be examined by direct evaluation to gain further pathophysiologic insight.
To further assess erythroid differentiation, cells were harvested from the CFC plates and subjected to morphologic evaluation on Giemsa-stained Cytospin preparations (Fig. 8) and to flow cytometric immunophenotyping (Fig. 9).
Morphologic evaluation, immunohistochemistry, in situ hybridization and enzyme immunoassay (EIA) analyses were applied.
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