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In a posterior work, Shea and Bailey [31] evaluated body proportions in order to test the hypothesis that morphologic differentiation of African pygmies can be explained by the differential extension of a common growth pattern (i.e. ontogenetic scaling).
The degree of morphologic differentiation was reflected by the levels of mucin and constitutive E-cadherin expression.
WT1 expression was restricted to the cytoplasm of sympathetic neuroblasts, while it progressively disappeared with advancing morphologic differentiation of these cells along both ganglionic and chromaffin cell lineages.
First, we described the development of crown architecture by following the growth of the crown in 15 young individuals, with special attention to growth and branching models and to the morphologic differentiation of axes.
All tissues showed a similar degree of morphologic differentiation and thickness that was similar to control tissues that developed in the presence of mature fibroblasts (Figure 5A).
Since cranial morphology would be associated with postcranial morphology, other hypotheses have been tested in order to get more insight on biological mechanisms of morphologic differentiation.
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To evaluate the effects of TrkB gene silencing on morphologic cell differentiation, cells were transfected with TrkB-specific or non-related siRNA as reported in Cell Culture and siRNA trasfection.
After the appearance of morphologic features of differentiation, cells were used for histochemical study.
In addition, downregulation of giant cell markers was not accompanied by changes in the morphologic assessment of differentiation, as the percentage of giant cells and syncytiotrophoblast remained the same with or without rosiglitazone (data not shown).
Abelson et al. reported that putative ovarian CSCs with different levels of morphologic and tumorigenic differentiation display microenvironment-dependent plasticity with the capacity to restore self-renewal and CD44 expression [ 49].
When CBS cells were grown in Ca2+-free medium and then switched to medium supplemented with 1.4 m M Ca2+, proliferation was reduced and morphologic features of differentiation were expressed.
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