These morphologic changes suggested that sustained PERK activity triggered apoptosis in addition to impairing cell proliferation.
Biventricular systolic function and electrocardiography QRS width appear less affected, suggesting morphologic changes in TOF and its repair that extend beyond the effects of PR.
Genomic and genetic studies as well as the pure observation of morphologic changes during the iPSC induction process suggest that mesenchymal-to-epithelial transition (MET) or blocking the opposite process epithelial-to-mesenchymal transition (EMT) is required for the reprogramming (Li et al., 2010; Samavarchi-Tehrani et al., 2010).
Furthermore, analyses of breast tissue from human autopsy and surgical specimens suggest that additional morphologic changes in the epithelium repeatedly occur during each menstrual cycle [ 5].
This suggests that the morphologic changes were unrelated to HPV and were misclassified as CIN2.
Although Wnt7a down-regulation is transient after estrogenic exposure, subsequent morphologic changes became more pronounced during postnatal and adult life, suggesting that the female reproductive tract is permanently reprogrammed after exposure even to weak estrogenic compounds.
Hence, it has been suggested that, in combination with volumetric changes, the morphologic changes of liver metastases such as, sharpness of the rim and the heterogeneity of contrast enhancement seen on CT or magnetic resonance (MR) may also be useful for evaluating response.
These CPE-like morphologic changes were not observed in the uninfected or inactivated samples, which suggests that the NV stock was able to induce gross morphologic changes in the 3-D intestinal aggregates.
The morphologic changes that were elicited by PCBs and DES were different immediately after exposure, suggesting that Wnt7a-independent pathways are also activated by one or both of these compounds.
Morphologic changes such as cell shrinkage, externalization of cell membrane phosphatidylserine, DNA fragmentation, and nuclear condensation suggest that M-LR causes rapid apoptosis in hepatocytes.
