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Morphologic changes such as cell shrinkage, externalization of cell membrane phosphatidylserine, DNA fragmentation, and nuclear condensation suggest that M-LR causes rapid apoptosis in hepatocytes.
Various morphologic changes such as PED, bulge of RPE, and subretinal fluid in eyes with CSCR were reported using SD-OCT [ 23- 26].
Human AAA tissue manifested the characteristic morphologic changes, such as local elastin degeneration, accumulation of necrotic cells, intra-aortic bleeding in vascular tissue (Fig. 1A).
Simultaneously, the massive reabsorption of monoclonal FLCs within the proximal tubules induces proximal tubule cells apoptosis and DNA degradation, resulting in critical morphologic changes, such as epithelial-to-mesenchymal transition (EMT) or necrosis [ 21].
Although ultrasonographic findings and indocyanine green (ICG) are typically most helpful in diagnosis, OCT can also be used to evaluate secondary retinal morphologic changes, such as shallow subretinal fluid or cystoid macular oedema.
Regular assessment of body weight and body composition can help in the early detection and treatment of morphologic changes, such as the loss, accumulation, and/or altered distribution of fat as well as AIDS wasting syndrome.
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Fluorescent signals were detected in nucleic regions of cells after 4 h of treatment with 50 ng/ml rhIL-25, and more obviously, morphologic changes of apoptosis such as condensed chromatin and shrunken nucleus were detected after 24 h of treatment.
In contrast, for the ulnar component, such morphologic changes would impose difficulty in placing the press-fit model despite an anatomically designed stem.
a Mycelia of untreated (control) P. digitatum with linearly shaped hyphae; b, c P. digitatum treated with MIC of α-terpineol (arrows refer to the morphologic changes in the hyphae, such as warty surfaces); d, e P. digitatum treated with MFC of α-terpineol (arrows refer to the morphologic changes of collapsed cell and irregular branching).
Hence, it has been suggested that, in combination with volumetric changes, the morphologic changes of liver metastases such as, sharpness of the rim and the heterogeneity of contrast enhancement seen on CT or magnetic resonance (MR) may also be useful for evaluating response.
Nonetheless, published data suggest at least three possible applications for lung MRI in ILD: (1) visualisation and recognition of morphological changes and their patterns, (2) assessment of the inflammatory activity of the disease and (3) effects of lung morphologic changes on functional parameters such as contrast enhancement and perfusion.
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