The most severe morphologic changes, including electron-dense mitochondrial inclusions, were found in the fetuses with delayed recovery of the fetal heart rate after the final occlusion.
Livers of 24-month old individuals showed extensive morphologic changes, including spongiosis hepatis, steatosis, ballooning degeneration, inflammation, and nuclear pyknosis.
However, morphologic changes including inflammation, foci of apoptosis and necrosis, and hepatocellular degeneration were observed in arsenic-treated mice.
CHD was defined as the presence of right-sided valvular regurgitation or stenosis (excluding both trivial or mild findings [ 23]) plus morphologic changes including thickening, shortening, retraction, hypomobility or incomplete coaptation of the affected valves [ 2, 4].
The significant morphologic changes, including shrinkage of cytoplasm, fragmented nuclei and release of apoptotic vesicles in HSG tumor mass, were also observed by the microscopic analysis (Fig. 5C, right).
In both PANC-1 and BxPC-3, the combination of SAHA and ML-60218 produced morphologic changes including cell enlargement and flattening, irregular shapes with cytoplasmic projections, accumulation of cytoplasmic vacuoles, and nuclear fragmentation.
Morphologic changes include reduced cell proliferation in dentate gyrus and decreased neurogenesis in hippocampus evoked by a spatial learning task.
Following treatment, predominant morphologic changes included increased multinucleated histiocytes and degenerated cells, decreased duct extension, and prominent periductal fibrosis.
These observed morphologic changes included changes in size, shape, and clumping of cells, and detachment of cells from the beads on which the cells had been cultured.
Apoptosis is characterized by morphologic and biochemical changes including cell shrinkage, chromatin condensation, and DNA fragmentation [16].
Amphibian metamorphosis is totally dependent on T3 and is associated with dramatic morphologic and physiologic changes, including cell death, division, or differentiation (Dodd and Dodd 1976).
