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We found that under interstitial flow (average 10 μm/s for 6 days), both cell types underwent drastic morphologic changes from static conditions: LECs formed large vacuoles and long extensions, while BECs formed multicellular branched lumen-containing networks.
Consistent with the results of HPIP modulation of GC cell migration and invasion, HPIP overexpression induced EMT, with the activation of morphologic changes from a polarized epithelial phenotype to an elongated fibroblastoid phenotype (Fig. 5a).
Moreover, SACC-LM cells transfected with plasmid containing MTUS1/ATIP3a cDNA displayed obvious morphologic changes, from irregular fibroblast-like shapes to circular or ovoid shapes (Additional file 9: Figure S5).
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There is a drastic morphologic change from the visceral epithelium to the proximal tubule at the exact junction where filtration function ceases and resorptive and secretory functions commence.
Boyer and colleagues first described a morphologic change from epithelial-like sheets of cultured cancer cells to scattered, fibroblast-like cells capable of invading the basement membrane, so called epithelial to mesenchymal transition (EMT) [ 1].
To analyze ovarian and uterine morphologic changes resulting from intrauterine and postnatal exposure to diesel exhaust.
Lymph node abnormalities in patients can be varied, showing spectrum of morphologic changes ranging from reactive lymphadenitis, opportunistic infections, Kaposi's sarcoma, malignant lymphomas.
Peripheral blood smears showed microcytosis and spherocytosis of hema6 RBCs, and SEM highlighted morphologic changes in the erythrocytes from homozygous mice with stomatocytes, spherocytes, and membrane blebbing.
Cabozantinib significantly reduced the cell number and viability, whereas methotrexate was minimally effective as evident from morphologic changes and the 3- 4,5-dimethylthiazol-2-yl -2,5-diphenyltetrazolium bromide (MTT) assay.
Overall, when ATN was absent, studies reported a wide variety of kidney morphologic changes in septic AKI – ranging from normal (in most cases) to marked cortical tubular necrosis.
To investigate the morphologic changes in Supramid Extra suture harvested from patients displaying recurrent ptosis who had undergone a frontalis suspension for congenital ptosis.
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