We hypothesized that the diffuse reflectance intensity decreases during the transformation of tissue from healthy to dysplastic due to morphologic, cytologic and vascular changes associated with transformation.
Using subcutaneous tumor models, we correlated early morphologic and functional vascular changes following treatment with aflibercept to long-term tumor growth inhibition (TGI).
Ultrasound imaging offered both endpoints including % vascularity and vascular perfusion rate to detect the morphologic and functional changes in tumor vasculature after therapy.
Pathological vascular remodeling, such as neovascularization, angiogenesis, and morphologic changes in vascular architecture, is a critical process in the development of vascular diseases including atherosclerosis, cardiovascular ischemic diseases, tumor vasculogenesis, and liver fibrosis.
Its main feature is the extensive presence of atherosclerosis, which is anticipated by morphologic and functional changes involving vessel wall and vascular endothelium.
This paper reviews the role of different ultrasound modalities (from morphologic to vascular assessment) in initial management of primary melanoma and outlines the development and importance of new functional ultrasound modalities for monitoring antiangiogenic or antivascular treatments.
In addition, these adipose-derived stem cells acquired several morphologic and molecular endothelial phenotypes when exposed to growth factors (endothelial cell growth supplement and vascular endothelial growth factor) and physiologic shear stress in vitro.
Specialized in Internal Medicine and Vascular Diseases.
Her father is a thoracic and vascular surgeon in Greensburg.
Aneurysms and vascular dissection.
