However, the morphologic change and expression of synaptophysin and chromogranin was not evident in these patients.
The aim of our study was to investigate the role of morphologic parameters and expression of cells cycle regulators as prognosticators in GIST.
It is well known that both the morphologic and molecular expression of cells depend, in part, on the local mechanical environment, especially for cells such as endothelial cells that experience shear stress, stretch, and pressures.
We have previously generated an immortalized cell line of human microglia, HMO6, which carries morphologic and phenotypic expression characteristic of primary human microglia [18], [19].
Using this approach, we demonstrated that hypoxia (1% O2) led to morphologic and gene expression changes that were consistent with EMT, and furthermore enhanced the migratory ability of PTECs in a HIF-1-dependent fashion.
To investigate whether GC7 could regulate doxorubicin-induced EMT, we examined morphologic changes and expressions of EMT markers in bladder cancer cells treated by GC7 with or without doxorubicin.
In a previous study, we showed that activation of a transfected human erythropoietin receptor (EPOR) in the murine myeloid cell line 32D resulted in the development of morphologic features of granulocytic differentiation and expression of the neutrophil primary granule protein myeloperoxidase.
DTs were used at early passage and their morphologic and molecular characteristics, including gene expression profiling, resemble the original patient tumours from which they were derived (Bayliss et al, 2007).
Knockdown of STAT3 expression by siRNA induces morphologic and biochemical changes consistent with apoptosis in several astrocytoma cell lines, but not in primary human astrocytes.
This may suggest that they are intracytoplasmic follicular lumina rather than secretion vacuoles and represent the morphologic expression of an arrest in folliculogenesis [ 17, 18].
