For lymphocyte and neutrophil quantification, 20 random H&E fields (magnification, 40×) from three animals of each genotype were scored for the presence of these cell types based on well-established morphologic criteria, and cells within the vasculature, ductal lumina, or intrapancreatic lymph nodes were excluded.
Typical morphologic characteristics like spikes and cell clustering were absent.
EMT is an evolutionarily conserved program in which cells lose their epithelial features and acquire mesenchymal properties through a process involving cytoskeleton remodeling and cell morphologic changes, resulting in increased invasiveness [3].
The structural information is complemented by kinetic, binding, and cell morphologic analyses of the constructs used for the crystallographic studies as well as the effects of various site specific mutants.
In particular, metastasis from renal cell carcinoma shares morphologic and imaging features with nonhyperfunctioning islet cell carcinoma.
Apoptosis is characterized by morphologic and biochemical changes including cell shrinkage, chromatin condensation, and DNA fragmentation [16].
These observations indicate that morphologic and functional aspects of cell death are not necessarily linked to each other.
Amphibian metamorphosis is totally dependent on T3 and is associated with dramatic morphologic and physiologic changes, including cell death, division, or differentiation (Dodd and Dodd 1976).
It is well known that both the morphologic and molecular expression of cells depend, in part, on the local mechanical environment, especially for cells such as endothelial cells that experience shear stress, stretch, and pressures.
IKKα overexpression led to both morphologic and molecular changes in cells that were comparable to well differentiated NP69 and CNE1 cells [ 4].
