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Here we report combined molecular genetic and morphologic analyses of normal human ovarian tissues and early stage cancers, from both BRCA mutation carriers and the general population, indicating that EOCs frequently arise from dysplastic precursor lesions within epithelial inclusion cysts.
From morphologic analyses of testes, treatments 4 and 5 yielded better histological changes.
We next examined the cell cycle response to paclitaxel using DNA analysis and morphologic analyses of chromatin in each of the four breast cancer cell lines.
The structural information is complemented by kinetic, binding, and cell morphologic analyses of the constructs used for the crystallographic studies as well as the effects of various site specific mutants.
Rodent species were identified on the basis of morphologic analyses of formalin-fixed carcasses; chromosomal data and mitochondrial DNA sequencing of the cytochrome b gene were used to confirm identification of most antibody-positive animals.
For morphologic analyses of uterus, we recorded known E2-induced features including shape and polarity of the lamina propia cells, epithelial mitotic figures and necrosis, determination of hypertrophy and hyperplasia of glands and endometrial epithelium, and pathologic features such as squamous metaplasia and pyometra.
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Upon gross morphologic analyses, ovx animals had very low uterine weights; in animals treated with either E2 dose, uterine weight was increased to the range of that of intact animals.
For sparse labeling of neurons without selection for a particular subtype, the R26CreER Z/AP combination with an early postnatal injection of 4HT generates a frequency of labeling that is close to optimal for morphologic analyses [ 0.001% 0.01% of neurons labeled; 5,10].
With respect to tumor vascularization, the possibility of the formation or lining of a microcirculation by tumor cells has been suggested by several studies, on the basis of morphologic analyses and numerous pathology reports [ 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25].
In morphologic analyses we found that a majority of the mass was fibrous and composed of many types of fibers (e.g., mineral wool, fiberglass, asbestos, wood, paper, and cotton).
FITC fluorescein isothiocyanate TRITC tetramethylrhodamine isothiocyanate W.C.P. designed and directed the study and did most of the photography and morphologic analyses.
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