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This array of morphologic alterations is known as diffuse alveolar damage.
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These morphologic alterations were associated with a concomitant reduction of H, SDH, and LDH-X specific activities.
Other significant morphologic alterations were recession of the lesser tuberosity and medial displacement of the bicipital groove.
Figure 1A represents a typical slide from saline-treated rats, in which no morphologic alterations are present.
However, no tumors, pre-neoplastic changes or other CNS morphologic alterations were detected, suggesting that postnatal aberrant Wnt activation is not sufficient to induce CNS tumorigenesis in mice.
Morphologic alterations were detected in 76% of the patients, with reticular and ground-glass patterns the most frequent abnormalities; however, these alterations were limited to less than 25% of lung parenchyma.
No tumors or morphologic alterations were detected in the brains of transgenic mice expressing stabilized β-catenin, suggesting that postnatal Wnt signaling in differentiated neurons may not be sufficient to induce CNS tumorigenesis.
The morphologic alteration was monitored under phase contrast microscope every day.
At month 1, 3 different types of morphologic alteration could be identified and described in detail over the course of the study.
However, aborted fetuses and stillborn and distorted nonviable newborn fawns are almost impossible to collect in the wild (quickly eaten by scavengers), and the absence of SBV-specific genetic material or morphologic alterations at necropsy are not evidence of noninfection.
Therefore these morphologic alterations need to be assessed in the context of the other videocapillaroscopic parameters.
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