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After exposure to AEF, abnormal mitotic configurations that closely resemble morphologic abnormalities were observed with agents that interfere with microtubule polymerization, such as paclitaxel [53].
Concomitantly, proteinuria and other morphologic abnormalities were significantly reversed.
No externally visible morphologic abnormalities were observed in each treatment group in either experiment.
All of these transgenic lines behaved similarly to the wild-type controls and no gross clinical or morphologic abnormalities were observed in the transgenic lines.
Morphologic abnormalities were classified as edema or swelling, skin blistering, craniofacial malformations, and/or four types of axial malformations (dorsal flexure, lateral flexure, wavy tail, and axial shortening).
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The issue of painful, autonomic, and nerve morphologic abnormalities are discussed in subsequent sections.
Interestingly, the prevalence of cartilage and meniscus morphologic abnormalities was similar between controls and subjects at risk for OA.
> Genomic instability is a major driving force of tumorigenesis that might occur in normal tissues even before morphologic abnormalities are detectable [ 31].
While the prevalence of morphologic abnormalities was similar between groups, the mean T2 significantly differed, indicating that subjects at risk for OA have altered cartilage biochemistry.
A reduction in the thickness of all peripapillary RNFL quadrants as measured by OCT has been reported [ 12, 43], and it has been suggested that this morphologic abnormality is related to retinal dysfunction as revealed by abnormal patterns in electroretinogram responses [ 43].
This morphologic abnormality was not associated with acetabular dysplasia determined by LCE angle <25°, Tönnis angle >10° or ACE angle <25°.
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