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Tissue morphogenesis is mediated by multiple extracellular matrix components and by multiple active sites on some of these components.
To explore whether cooperation of c-Abl with Lpd in axonal morphogenesis is mediated by Ena/VASP proteins, we co-overexpressed c-Abl and Lpd with or without FP4-mito or AP4-mito constructs to delocalize all Ena/VASP proteins.
These results corroborate in vitro studies that have demonstrated that estrogen-dependent mammary epithelial proliferation and/or ductal morphogenesis is mediated through the paracrine action of estrogen-induced, stroma-derived factors.
Thus, other work has demonstrated that adipose tissue-derived MSC activation of endothelial cells and subsequent vessel morphogenesis is mediated preferably via the serine proteases of the plasmin family including urokinase-type plasminogen activator in conjunction with hepatocytes growth factor and tumor necrosis factor-α (TNF-α) which contribute to vessel enlargement [ 63].
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These previous studies have established the notion that GH and estrogen synergistically stimulate ductal morphogenesis, which is mediated by stromal cell-produced local IGF-1 in mammary tissues.
We conclude that GSK-3 is a critical regulator of neuronal migration and morphogenesis and that GSK-3 regulation is mediated by phosphorylation of key cytoskeletal proteins.
These data indicate that the Shroom3-Rock interaction is vital for neural tube morphogenesis and that the majority of Shroom3 activity in apical constriction is mediated by Rock.
Technology is mediated through society.
Touch is mediated by cutaneous mechanoreceptors.
The diminished outgrowth potential indicates a continued requirement for normal macrophages during ductal morphogenesis and may be mediated by effects on the putative basal progenitor cell.
Indeed, contrary to reports in the salivary gland, we found that neural regulation of airway morphogenesis is not mediated by cholinergic neurotransmitter discharge at this phase of development during the early ramification of the bronchial tree.
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