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Interfacial migration is central to multiple processes including morphogenesis and wound healing.
Together, the complex biological and physicochemical properties of HA influence key developmental processes such as embryogenesis, morphogenesis and wound repair.
Tissue dynamics during dorsal closure, a stage of Drosophila development, provide a model system for cell sheet morphogenesis and wound healing.
This type of movement occurs in vivo during morphogenesis and wound repair [19].
Here we report that Activin A, a TGFβ family member induced by pro-inflammatory cytokines and involved in skin morphogenesis and wound healing, induces the differentiation of human monocytes into LC in the absence of TGFβ.
Typically, these pathways are also active in other processes, including cell proliferation, apoptosis and differentiation during early developmental stages, tissue morphogenesis and wound healing.
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Biological assays, an alamarBlue™ viability assay, anchorage-independent growth (soft agar colony formation and foci formation), two-dimensional and three-dimensional morphogenesis, and wound-healing assay was performed as previously described [ 23].
Indeed, heparan sulfate PGs have been nominated to be the master regulators of MSC proliferation and differentiation in the bone marrow niche as well as during tissue morphogenesis, neovascularisation and wound repair [ 41].
FGF-1 has various biological functions and has been associated with various stages of morphogenesis, tissue repair, angiogenesis and wound healing [ 3, 4].
Such experiments will provide more insights into specific mechanisms of mechanotransduction and cell behavior, which are crucial to processes such as morphogenesis, stem cell differentiation, metastasis and wound healing.
Two other clusters are activated in some luminal and HER2+ tumors and are enriched for genes involved in embryonic appendage morphogenesis, ossification, regionalization, negative regulation of macromolecule synthesis, and wound response (Additional file 4).
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