The most notable processes altered at later developmental stages were calcium and iron metabolism, embryonic morphogenesis including neuronal and retinal development, a variety of mitochondria-related functions, and generalized stress response (not including induction of antioxidant genes).
Because CG6750 is likely to be the homolog of zebrafish pob, we designated CG6750 as ' dPob' and analyzed its functions in Rh1 transport and retinal morphogenesis.
crb1 contributes to photoreceptor morphogenesis and sensitivity, mutations cause retinal degeneration in humans, mice, and flies (Bulgakova and Knust 2009).
Some of these SirT1-regulated genes have long been recognized as key factors in neuro-retinal morphogenesis, and their misregulation in the absence of SirT1 could account for the specific phenotype of the KO mice, which particularly affects ectodermal patterning.
Meis1 is a member of TALE (Three Amino acid Loop Extension) homeodomain transcription factors involved in many processes of vertebrate development and morphogenesis, e.g. maintaining RPC status, regulating the expression of key retinal developmental genes and retinal development in vertebrate species (Heine et al., 2008; Erickson et al., 2010).
In this review, the author focussed on cell and tissue morphogenesis during fly retinal development, including the regulated changes in cell shape and cell packing that ultimately determine the shape and architecture of the compound eye.
Severe myopia also carries a risk of sight-threatening conditions such as retinal detachment, glaucoma and retinal degeneration.
"Shredded iris and retinal detachment," he told me.
These include cataracts, retinal atrophy and retinal dysplasia.
