The structural organization and dynamic remodeling of the cytoskeleton and its association to the secretory pathway are critical determinants of cell morphogenesis and migration.
Marlin-1 associates to the cytoskeleton in neurites, is required for the maintenance of an intact Golgi apparatus and its depletion produces the down-regulation of kinesin-1, a plus-end directed molecular motor with a central function in morphogenesis and migration.
Here we demonstrate that Abi2 modulates cell morphogenesis and migration in vivo.
MP1 and p14 also play important roles in cell morphogenesis and migration.
Ventral stress fibers play an important role in cell adhesion, morphogenesis and migration, but how these and other contractile actomyosin bundles are generated has remained elusive.
To date, at least 25 Rho GTPases have been identified in human cells where they regulate various cellular processes including actin polymerization, microtubule dynamics, cell cycle and transcriptional regulation, morphogenesis and migration (Etienne-Manneville and Hall, 2002).
The networks described a prominent enrichment for known cancer hallmarks [ 74] with significant GO subnetworks related to immune response, cell cycle, signal transduction, DNA repair, translation, proteolysis, metabolic terms such as respiration and cell morphogenesis, adhesion and migration.
Rapid membrane dynamics are crucial for many cellular processes, including endocytosis, intracellular trafficking, cell morphogenesis, and cell migration.
On top of the HG-overrepresentation lists one finds gene sets related to homeostasis for high expression (a) and to morphogenesis and cell migration for consistently highly ranked genes (b) (see Table 2).
Dear Editor, Endocytosis is a crucial process employed by cells to internalize nutrients and turnover membrane components and is essential for many functions, including nutrient uptake, signal transduction, cytokinesis, morphogenesis, cell adhesion and migration.
MMPs have a broad spectrum of proteolytic activities towards extracellular matrix (ECM) components, and are believed to be involved in several biological processes including embryo implantation and morphogenesis, cell migration, metastasis, tumor invasion and wound healing [ 15, 16].
