Activated Stat3 mediates signals downstream of the HGF/c-met pathway [ 20], and Stat3 has been shown to be essential for HGF-induced morphogenesis and for invasive behavior driven by c-met in both fibroblasts and breast carcinoma cells [ 39- 41].
We therefore hypothesized that overexpressing sgl should prevent dGALT mutant phenotypes by antagonistically increasing Dlp levels, thus acting to limit Wg abundance to properly control NMJ morphogenesis and coordinated movement behavior.
Mutagenesis screens to identify and characterize genes that control fundamental biological mechanisms such as those that underlie gene regulation, chromosome organization and mechanics, cell growth and differentiation, pattern formation, sex determination, morphogenesis, cell cycle control, and behavior.
The GO categories overrepresented among the genes with significantly greater expression in Africa indicate that these genes, in addition to playing roles in transport and energy metabolism that are expected for the Malpighian tubules, are also involved in male courtship behavior, morphogenesis, and growth (Table 3; Table S5).
It is well known that certain functions are found in only specific parts of the evolutionary phylogenetic tree, e.g. those involved in morphogenesis, organ development, differences in brain function, and behavior.
Our results demonstrate the differential effects of the S252W and P253R FGFR2 mutations on palatal morphogenesis and reveal the aberrant cellular behaviors associated with the phenotypic differences between Fgfr2 +/S252W and Fgfr2 +/P253R Apert syndrome mice.
In accordance with a perceived role of SUB in coordinating cellular behavior in tissue morphogenesis and cell patterning, SUB acts in a non-cell-autonomous fashion and mediates inter-cell-layer signaling across histogenic cell layers in the ovule, the floral meristem [ 5] and the root [ 7].
Most of these studies have focused on transcription factors involved in embryogenesis and morphogenesis, leaving unknown to what extent the molecular components that regulate physiology and behavior are conserved.
Imaging morphogenesis in live embryos and tissues has revealed that cells are much more dynamic than previously thought, changing their shape and behavior in ways that our interpretation of successive static images of developmental stages could not have predicted [1] [5].
Adult language and behavior.
