Reelin is a multifunctional signal that coordinates cortical and subcortical morphogenesis during development and regulates structural plasticity in adulthood and aging.
Our hypothesis is in concordance with recent data showing that TCs are involved in tissue morphogenesis during development (Zheng et al. 2014a) and play a part in regeneration and aging (Zheng et al. 2014b).
Altogether, we conclude that the EGFR pathway regulates cell morphogenesis during enterocyte maturation and that this process is critical during normal development of the adult gut, compensatory renewal following infection and aging.
Biological processes associated glioblastoma survival included morphogenesis, cell cycle, aging, response to stimuli, and programmed cell death.
Careful examinations of the genes involved in biological process of these two cDNA libraries revealed that much more genes specifically expressed in the RAMOS cell line were involved in the process of cell differentiation and non-developmental growth, such as aging, death, morphogenesis and pattern speciation, indicating the non-uniformity development of the RAMOS cells.
It constitutes a systematic means of cell suicide during normal embryonic development and morphogenesis (von Wangenheim and Peterson, 1998), aging (Monti et al, 1992) or in response to pathogenic infections and other irreparable cell damage.
These processes included: aging, morphogenesis, cell cycle and proliferation, and death for lifetime survival; morphogenesis for overall survival; and cell cycle, death and recognition, death, response to biotic and abiotic stimuli, programmed cell death, and apoptosis for progression-free survival.
Thus, homeobox transcription factors may not only function in morphogenesis and differentiation but they might also be involved in the process of aging.
For instance, spine morphogenesis and glutamatergic neurotransmission in cortex, but not hippocampus, are significantly reduced in KALRN knockout mice, and these mice exhibit age-dependent behavioral deficits such as reduced working memory, sociability, prepulse inhibition, and hyperactivated locomotion [ 45].
They are involved in photosynthesis, growth, morphogenesis, and reproduction.
