Sentence examples for morphine can induce from inspiring English sources

However, the opposite is the case at nerve terminal receptors where, if PKC is activated, morphine can induce significant rapid MOR desensitization whereas DAMGO and Met-enkephalin cannot.

Thus, morphine can induce acute strong tolerance via the glutamate N-methyl d-aspartate acid receptor (NMDAR)/neural nitric oxide synthase (nNOS /zinc metabolism (45, 47).

In conclusion, we show that morphine can induce robust desensitization of endogenously expressed MOPrs in mature neurons both in vitro and in vivo, and that this desensitization requires ongoing activation of PKC.

Alternatively, several in vivo studies provided evidence that morphine can induce tumor growth by upregulation of cyclooxygenase-2 (COX-2) [ 37– 40] and or prostaglandin E2-mediated stimulation of angiogenesis [ 41– 41].

Alternatively, several in vivo studies provided evidence that morphine can induce tumor growth by the upregulation of cyclooxygenase-2 (COX-2) [ 35– 38] and/or prostaglandin E2-mediated stimulation of angiogenesis [ 39– 42].

Repeated morphine exposure can induce behavioral sensitization.

Repeated morphine administration can induce the neurochemical effects including mainly protein components and neurotransmission adaptations in the brain, which results in behavioral response underlying opioid dependence [ 1].

Although the desensitization induced by morphine was slightly less than that induced by DAMGO and developed over a longer time period, it is evident that prolonged morphine exposure can induce robust loss of MOPr function in adult mammalian neurons.

It appears therefore that exposure to DAMGO induces MOPr desensitization that is both rapid in onset and extensive, whereas morphine-induced MOPr desensitization develops more slowly, requires ongoing PKC activation, but both in vitro and in vivo morphine treatment can induce a similar level of loss of receptor function.

Although rapid agonist-induced desensitization of presynaptic MORs is not induced by the high-efficacy agonists DAMGO and Met-enkephalin, morphine can cause rapid desensitization when PKC is activated.

Prenatal morphine exposure throughout pregnancy can induce a series of neurobehavioral and neurochemical disturbances by affecting central nervous system development.