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Vomiting was observed only after morphine administration.
Chronic morphine administration induces neurochemical adaptations in the noradrenergic system.
Intermittent morphine administration produces greater hyperactivity than acute morphine.
Morphine administration may cause respiratory depression, hypotension, dizziness, mental confusion, constipation, itching, urine retention and nausea.
Respiratory frequency was dose-dependently and significantly decreased after morphine administration.
However, observational data suggest that morphine administration during MI may have negative consequences.
Acute morphine administration produces hyperactivity in mice and repeated treatment induces an enhancement of this effect.
Moreover, p53 expression in the spinal cord had increased significantly 14 h after the last morphine administration.
Conclusions: Despite decreased postoperative morphine requirements, intrathecal morphine administration did not have a clinically relevant effect on extubation time after CABG surgery.
Chronic morphine administration (5 days, 100 mg/kg, twice daily) resulted in a 2.8-fold rightward shift in the morphine dose-effect curve.
The present study was designed to investigate how chronic adolescent morphine exposure could affect the responsiveness of lateral paragigantocellular (LPGi) neurons to acute morphine administration in adult rats.
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