Moreover, when we used human autopsy CNS material, similar staining patterns were observed (Figure 4).
Moreover, when we used continuous exposure variables, the picture was similar, i.e., the higher effect estimates, the longer time that had passed between the baseline examination and the time to diagnose (data not shown).
Moreover, when we used a reporter that contains three target sites complementary to endogenous let-7a, we observed no change in luciferase expression (supplementary Fig S7 online).
Moreover, when we used the MBD domain to tether KDM2A, a closely related H3K36me1/2 demethylase that does not interact with PRC1 components (Blackledge et al., 2010, Farcas et al., 2012), we failed to observe either H2AK119u1 or H3K27me3.
Moreover, when we used small current steps to evaluate the onset and steady state input resistance (Rin; Figure 4D; 'Materials and methods'), we found that onset Rin was not different among control, tinnitus, and non-tinnitus mice.
Moreover, when we used them for a reciprocal BLAST query against the human proteome, the best scoring hits were γ subunits of Cav, suggesting that these might be true homologs.
Moreover, when we used a regression model, adjusted on the litter size, to analyze these data (GEE), the day 1 body weight of BPA-exposed animals remained higher, both for male (p < 0.001) and female (p < 0.001).
Moreover, when we used mean regression to conduct mediation analyses in the same cohort (with air pollution as exposure, methylation as mediator, and cardiovascular-related blood markers as outcomes), we estimated a positive indirect effect of PM2.5 black carbon on fibrinogen through a decrease in F3 methylation (Bind et al. 2014).
Moreover, when we used established methods to estimate the equilibrium level of heterozygosity (πs) expected from germline mutation among 16 strains, we obtained a value of approximately 1,900 heterosites across 500 Mb (chromosomes 1 3), which is in reasonable agreement with a conservative estimate of approximately 3,000 authentic variants.
