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In addition to illustrating pTDP-43 in cortical and hippocampal areas rostral and caudal to the injection, these heat maps also show TDP-43 accumulation in other more widespread brain regions in a time-dependent manner, such as the nucleus accumbens (Fig. 5a d), the lateral septum (Fig. 5e h), and others.
This may reflect more widespread brain differences in pre-term compared to full-term babies ― but we're still not sure yet what the lasting impact of those differences might be, according to Rogers.
We also assumed that increasing complexity of the social interaction in scenarios describing both cooperation and deception and an interaction of three characters would lead to more widespread brain activation due to the higher processing load involved.
Functional imaging studies indicate that individuals with ADHD activate more widespread brain regions than controls during task performance (review: [ 68]).
Notably, we observed a more widespread brain engagement when processing high-demand incongruent trials with recruitment of dorsolateral prefrontal and midcingulate (aMCC/pMCC) cortices being expressed during vaccine-induced inflammation compared with the placebo condition.
The conceptualizing and reasoning associated with the expression of political opinions is not necessarily limited to structures or functions of the regions we identified but will require the involvement of more widespread brain regions implicated in abstract thoughts and reasoning.
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Sequestration appears to be patchy within microvascular networks of each organ, but is more widespread in brain than retina.
Unlike the focal ischemia model where extensive astrogliosis is found in the penumbral area, astrocytes in the BCCA brain are more widespread in different brain regions.
FRMD7 expression is not restricted to the oculomotor control center of the brain and so it is perhaps surprising that defects in FRMD7 function do not result in more widespread defects in brain development.
"However, the increased blood flow should have more widespread effects on brain function.
In hydrocephalus more widespread atrophy of brain tissue results from the abnormal amounts of fluid confined within the rigid bony compartment of the skull.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com