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Analysis of the functions of the P1/7 orthologues present in other streptococcal species identified that some functional groups are more widely conserved than others (Figure 3), and that some exhibit a wide range of distribution across the species compared.
This OCRE globular domain is a distinctive component of RBM10 and is more widely conserved in RBM10s across the animal kingdom than the ubiquitous RNA recognition components.
These results confirm that the criteria used for the QIPP scores can reliably distinguish between "orphan-like" (less well conserved) and "non-orphan-like" (more widely conserved) genes.
Thus, the oscillating, caudal domain may be an evolutionary novelty of higher vertebrates, and the more widely conserved stripe domain may fulfil a more fundamental role during segmentation.
The second DmTTF binding site, between trnS2 and nad1, is more widely conserved.
If a process is conserved between the two yeasts, it is likely to be more widely conserved.
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The promoters of many COR genes contain one or more copies of the widely conserved cis-acting element, C-repeat/dehydration response element (CRT/DRE) having the CCGAC core sequence [ 9], indicating that multiple cold responses are coordinately regulated by common regulators.
Tus proteins, which are shown to terminate replication in vivo, are more conserved in Proteobacteria and are not widely conserved in other, partly supporting the possible change in replication termination mechanism by a relatively recent takeover by the Tus-Ter system [ 43].
The term "widely conserved" will hopefully be given a more precise definition in the future.
Although TRBP was originally identified as the HIV-1 TAR RNA-binding protein, its more recently characterized function in microRNA biogenesis and RISC-activity is widely conserved in all cell types (e.g. epithelial, hematopoietic, mesenchymal cells etc...).
RRVR is located in the first, NC1, non-collagenous domain corresponding to a cleavage site that is widely conserved (Fig. 1c), but RKMR is predicted as a more likely furin cleavage site.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com