Your May 23 news article "College Entrance in China: 'No' to the Handicapped" depicts one more variant among the blatant human rights abuses in China.
Among Caucasians, more variants of 28 tagging SNPs of the NOS1AP gene were significantly associated with QT interval than in African Americans, Hispanics, and Chinese [ 90].
The size and morphology of a critical nucleus, comprising of one or more variants, are determined by the competition among bulk thermodynamic driving force, elastic strain energy, and interfacial energy.
In case of two or more variants with equal support, the random nucleotide was chosen among variants.
First, the cooperation among variants seems to undermine, rather than enhance, biodiversity: much more variants within a quasispecies survive in the case of pure competition between them than when some facilitation occurs.
This was also true when the subjects were divided into exposed and non-exposed groups, except for SULT1A1, which among exposed workers displayed more variant heterozygotes than expected.
Only variants detected by two or more variant-callers were selected leading to 156 missense mutations selected, among which 29 are already referenced in the COSMIC database.
Applying this meta-analysis method to multi-ethnic association studies has the disadvantage that it is targeted at the shared and more common risk variants among populations, whereas signals of population-specific risk variants will be diluted.
Thus, this analysis may greatly help to identify the really important variants among the more than 12 million SNPs in the human genome.
If these forces are acting, we should therefore see more GC→AT relative to AT→GC variants among polymorphisms, compared with substitutions between species.
