However, the probability to observe 3 or more variants among 148 individuals by chance based on the frequency of SLC7A3 variants in control populations is very low (p = 0.05), supporting an excess of SLC7A3 variants in patients with ASD.
However, the combined variant genotypes of the four loci with P trend) approaching to 0.10 (rs4253160, rs12571445 rs12571445 and rs3793784) were associated with a significantly increased lung cancer risk (adjusted OR 1.35, 95% CI, 1.04-1.75 among subjects carrying three or more variant alleles), indicating that multiple loci in ERCC6 may jointly contribute to the susceptibility of lung cancer.
Among Caucasians, more variants of 28 tagging SNPs of the NOS1AP gene were significantly associated with QT interval than in African Americans, Hispanics, and Chinese [ 90].
The size and morphology of a critical nucleus, comprising of one or more variants, are determined by the competition among bulk thermodynamic driving force, elastic strain energy, and interfacial energy.
In case of two or more variants with equal support, the random nucleotide was chosen among variants.
Only variants detected by two or more variant-callers were selected leading to 156 missense mutations selected, among which 29 are already referenced in the COSMIC database.
First, the cooperation among variants seems to undermine, rather than enhance, biodiversity: much more variants within a quasispecies survive in the case of pure competition between them than when some facilitation occurs.
Conformist bias occurs when individuals are disproportionately likely to acquire the more common variant from among the variants that they observe.
Our data suggest that the TOC1/PRR1 orthologs in S. moellendorffii, O. sativa and Arabidopsis represent a more recent and functionally divergent variant among the two component pseudo-response regulators.
Applying this meta-analysis method to multi-ethnic association studies has the disadvantage that it is targeted at the shared and more common risk variants among populations, whereas signals of population-specific risk variants will be diluted.
