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Taken together, our results show that USVs from wild California mice are of higher, more variable frequencies.
This indicates that the point where genes were expressed at the most even frequencies was reached around 40 DAA, and, from that point of development, the transcriptome changed to a distribution in which genes were expressed at more variable frequencies (a less informative transcriptome).
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Typical acoustic responses to potentially threatening challenges include changes in tempo-related features (e.g. call rate and duration) and source features (e.g. increased and more variable frequency and amplitude).
When seen from a pharmacological perspective, this represents an improvement compared with the CIA model, the current gold-standard arthritis model in the mouse, which has a lower and more variable frequency of disease incidence and a non-synchronized onset [ 38].
For example, rumbles produced in response to bees and white noise both exhibited increased and more variable fundamental frequencies, two common acoustic features associated with increased emotional intensity in other mammals generally [4] and in African elephants specifically [23], [27].
However, wild California mice produced USVs that were 2 8 kHz higher in median frequency and significantly more variable in frequency than laboratory California mice.
Male blackbirds have a large repertoire of songs with a stereotypic structure whereby each song starts with a motif part consisting of relatively simple low-frequency elements followed by a twitter part having more variable high-frequency elements (Fig. 1, Dabelsteen and Pedersen 1985; Ripmeester et al. 2007).
The inflammatory response of sepsis is developed in two phases, an inflammatory phase (SIRS) and a phase more variable in frequency and intensity (CARS): this balance has an important effect on morbidity and mortality.
More variables, more frequency, and with better integration [with] models".
Rainfall has become more variable globally, and the frequency of intense rainfall has increased in some areas.
DOI: http://dx.doi.org/10.7554/eLife.01741.002 Research by the Intergovernmental Panel on Climate Change (IPCC) indicates that the climate is becoming more variable and that the frequency of floods and droughts is increasing (IPCC, 2013).
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