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How do you justify that more variable features contain more information?
H/ACA box snoRNAs direct pseudouridylation, and often exhibit more variable features due to their shorter length of conserved elements and discontinuous complementary target binding regions.
Although the 5' exon-intron structure of UdGATA456 is more similar to the NvecGATA exon/intron structure, the 3' end of GATA456 orthologs exhibits more variable features.
If I understand correctly, the fact that humans/neurons should be more sensitive to more variable features is derived using a linear model with Gaussian input and channel noise.
The observed relationship contrasts with the more familiar 'whitening' regime (Srinivasan et al., 1982), which emerges when the main constraint is output capacity (e.g., with regard to the retina and the optic nerve bottleneck); the whitening regime predicts that fewer resources are allocated to more variable features.
This relationship, in which greater resources are allocated to more variable features, emerges from the efficient coding principle in the regime that the main constraint is input sampling (Barlow, 1961; van Hateren, 1992; Doi and Lewicki, 2014; Hermundstad et al., 2014).
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The 17p13.1 microdeletion syndrome is a recently described genomic disorder with a core clinical phenotype of intellectual disability, poor to absent speech, dysmorphic features, and a constellation of more variable clinical features, most prominently microcephaly.
Further examination of LMI specimens from Lake Malawi confirmed that LMI morphs have become more variable in these features than originally reported (Table 2; see also [ 21, 24]).
A more variable but prominent feature was the presence of numerous gammaH2AX (γH2AX) puncta in nuclei, this being a histone protein that is phosphorylated in response to DNA double-stranded breaks (DSBs).
This relationship between macro- and microstructural features becomes more variable for secondary and tertiary sulci (Fischl et al. 2008).
From this set, Figure 7 shows that a considerable amount was also caught by core elements (CCS and CCG flows) and a more reduced amount was handled by variable features (CVS and CVG). Figure 7 Exception flows signaled by core elements.
Related(20)
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