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VEGFR1, with more variable effects on endothelial cells, serves as a decoy receptor to regulate the activity of VEGF-A [30].
Strains belonging to the same species can induce fairly consistent plant growth promotion (e.g., Bacillus pumilus and Paenibacillus polymyxa strains) or have more variable effects on biomass production and RSA (e.g., Pseudomonas fluorescens strains).
Taken together, these data with endogenous p53 gene mutations support the conclusion that, in sum, p53 limits the life span of female flies, with smaller and more variable effects in male flies.
Mutations of the endogenous p53 gene also had sex-specific effects on life span under control and stress conditions: null mutation of p53 increased life span in females, and had smaller, more variable effects in males.
Results consistent with the transgenic manipulations were obtained from analysis of the endogenous p53 gene: Null mutation of the endogenous p53 gene increased life span in females, and had smaller, more variable effects on male life span.
However, more variable effects of 4-AP were reported in optic nerve axons, with Foster et al. [ 45] reporting relatively minor effects (compared to those on unmyelinated axons) while Devaux et al. [ 32, 33] found a profound broadening of the action potential, suggesting that these channels contribute different amounts to action potential repolarization in different axons.
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In previous studies, it has been found that oral ingestion of 150 mg/kg MSG increases sBP by 5-10 % for 30 60 min, with a more variable effect on dBP and heart rate, although heart rate usually declines [3, 5].
The sustained 24-h bronchodilator effect of a once-daily bronchodilator compared with the more variable effect of a twice-daily agent may also be relevant (fig. 4) [ 105].
Inspection of the resulting treeview diagram identified clusters of high Se-regulated expression in which 2 μg Se/g diet appeared to have a similar, albeit more variable effect.
Although treatment of HIV-infected individuals with HAART has had a significant effect on the burden of IPD in children (51% reduction), and a more variable effect in adults, the risk of IPD remains 28 to 42-fold greater in HIV-infected individuals than in the healthy population [ 2– 6].
This background did sensitize the sectoring phenotype of hst3Δ colonies as it did for wild-type colonies (compare the hst3Δ colonies between panels A and B in Figure 7 figure supplement 1), but it had a more variable effect on the frequency of half sectors, which is now discussed in the Results.
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