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Given the common finding of OPN in nontumour (infiltrating) cells, reported by Tuck et al (1998), it may be that OPN protein detection, when limited to quantification from only the tumour cells, may provide more useful predictive information than RNA levels quantified from tumour tissue, at least for breast cancer.
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Applying this understanding, we can effectively reduce the complexity of a model while its adaptability is retained, so it may become an even more useful and predictive tool.
In addition, Netzer's findings could help create more effective loan applications by offering strategies for wording questions in ways that generate more useful — and more predictive — answers.
Andrew Gelman, a professor of statistics and politics at Columbia University, thinks the idea of looking at aggregates is a good one, but the study's analysis of the behaviors of aggregates may be more useful than its predictive algorithm.
While patients with ER-α-positive tumors have a slightly better survival rate than patients with ER-α-negative tumors, expression of ER-α is more useful as a predictive factor for response to endocrine therapy.
The BB model may offer superior predictive properties amongst mapping algorithms considered and may be more useful when predicting EQ-5D-3L at poorer health states.
Similarly, there are clinical conditions with a high-baseline PCT like burns, major surgery, and systemic inflammatory processes, which is why PCT is much more useful for its negative predictive value.
Immunohistochemical analysis of tumour material from repeat biopsies during treatment may therefore help unravel the complex molecular mechanisms that ultimately determine clinical outcomes and thereby provide more useful and reliable intermediate predictive and prognostic factors.
The positive predictive value of elevated BNP levels alone remains low and its high negative predictive value is more useful to identify individuals with a likely favorable outcome.
Self-report questionnaires, which have a reasonable predictive power, are more useful in a busy, resource-limited clinical setting with moderate to high literacy population.
For the identification of elderly people who could benefit from an intervention that prevents ADL disability, it is more useful to know the 'short-term' predictive value of the physical frailty indicators.
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Justyna Jupowicz-Kozak
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