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Downstream blockade therefore has the potential to lessen the unwanted off-target effects associated with more upstream blockade.
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The specific mechanism of action of co-stimulation blockade, being more upstream in the immunological cascade as compared with TNF blockade, could theoretically lead to an even more pronounced effect when the agent is used very early in a disease.
We evaluated blockade of targets more upstream in the inflammation cascade, of activated macrophages and of IL-15.
Another $235m would upgrade more upstream locks.
"The more upstream you start, the more total control," he said.
You can imagine there's more upstream swimming for Diane.
Over time, as we have more upstream liquefied natural gas available, it will start flowing down to lower-priced markets.
Box has its eyes firmly set on becoming a real enterprise company, moving more and more upstream.
"We need more upstream shops," says Eileen.
Let's try to get a little bit more upstream from the problem.
"We need more upstream shops," says Eileen Theree's nothing for people coming to shop for or to look at".
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