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The present genomic comparison between obligate marine and non-obligate marine species of Shewanella clearly shows that marine species have evolved to contain more unique genes responsible for resistance to toxins and high osmotic pressure.
Since the non-epidemic animal and human isolates contained more unique genes than other epidemic strains, we speculate that the "accessory gene pool" available in these non-epidemic strains is being exchanged between strains, thereby enabling adaptive responses to new niches.
Analysis of genome variation revealed that LCT-KP289 contained more unique genes than LCT-KP214.
The strain with more unique genes is AK83, with 843 exclusive groups, while BL225C and Rm1021 have 469 and 602 exclusive groups, respectively.
Ley et al. (2006) estimated that the approximately 500 1,000 species residing in the human gut encode 100-fold more unique genes than the human genome.
The human gut harbors up to 100 trillion microbes, equivalent to 10 10 cells/g colonic content with a biomass of >1 kg [ 1, 2], which encode 100-fold more unique genes than the human genome [ 3].
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Another interesting finding is that, compared with the Chrysopicola clade, lineages within the Citri clade have more unique gene clusters.
Vibrio metoecus contains more unique gene families than V. cholerae that are involved in carbohydrate transport and metabolism (supplementary fig. S6 a, Supplementary Material online).
Therefore it is very likely that when the full mitochondrial genomes are sequenced from more members of this clade, more unique gene orders will be found and possibly more reversals to ancestral states will also be identified.
In addition, there were more unique gene expression signatures in early-late phase, for instances PTEN, BRAF, DDX5, NCOA4, WHSC1, CCND2, CDH11, ERCC5, FANCD2, LIFR, MAF, RAF1, and TOP1.
The number of specifically enriched GO terms in juvenile wood is about two times as in mature wood, suggesting more unique gene expression in juvenile wood than mature wood (Additional file 5).
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