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Using genomic DNA copy number alterations to substratify basal-like cancers into genomically more uniform groups could perhaps improve predictability, but this strategy will require considerably larger cohorts.
With this strategy, new subtypes of tumors can emerge or the existing classification may be redefined with the result of more uniform groups of tumors.
Meanwhile, smart integration of morphological and molecular information will lead to recognition of biologically much more uniform groups within the spectrum of diffuse gliomas and thereby facilitate tailored treatments for individual patients.
Our study was mainly aimed to obtain more homogeneous groups of tumors in colorectal adenocarcinomas hypothesizing that discovering molecularly more uniform groups of tumors, would likely discriminate patients with different clinical outcomes, as well.
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Whereas the first study population included six white, four black, and two Hispanic children, the latter study focused on a more uniform group of ethnically German children.
Chronic obstructive lung disease (COPD) patients (N = 27) were a much more uniform group, presenting high scores for dyspnea and lack of wellbeing.
While there are no absolute "best" criteria to optimize clustering, our main goal was to achieve more uniform grouping by minimizing the fractions of very large (>100 members) and singlet clusters.
This resulted in more uniform cluster groups than the heterogeneous pulsotype groups.
In contrast, the researchers found less family resemblance for joy and sadness--possibly because expression of these emotions is more uniform across groups.
However, some features are associated with more functionally uniform groups of proteins.
A more uniform patient group could have changed the results although in individuals there was also no correlation between measured variables over time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com