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The cysts in the animals which received albendazole sulfoxide loaded SLN every 48 h showed more ultrastructural modification.
More ultrastructural visualizations, like those produced by electron tomography [27], [28], could reveal more details of FC of these parasites.
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The observation that two of the imaged chRCCs were photopenic (both being classical variants) raises the possibility that more subtle ultrastructural differences underlie the variable appearance of chRCC on 99mTc-sestamibi SPECT/CT imaging.
Interestingly, yeasts of the acapsular mutant C. neoformans Cap 67 showed more drastic ultrastructural alterations than the other strains.
The non- MYCN amplified tumours had a more differentiated ultrastructural appearance, with frequent cell processes all appearing well developed with abundant NSG and NT,.
In beclin 1+/− mice also lysosomal abnormalities are noted, while their crossing with an APP-based AD mouse model results in higher intraneuronal and extraneuronal Aβ levels, more profound ultrastructural defects, including more severe lysosomal/autophagic abnormalities as well as increased neurodegeneration [ 107].
More recently, however, ultrastructural similarities and molecular phylogenetic affinities to Parvilucifera sp., a parasite of microeukaryotes, led to the establishment of the phylum Perkinsozoa, which like the Apicomplexa, is only comprised of endoparasites [ 11].
We also include a description of more unusual tumors with ultrastructural characteristics reported infrequently.
Following prolonged CSE exposure (120 min), ultrastructural characteristics more typical of necrosis were prominent.
Longer exposure times revealed ultrastructural characteristics more consistent with autophagy (60 min) and necrosis (120 min).
More recent studies on ultrastructural axonal changes showed microscopic damage after PRF exposure, abnormal membranes and morphology of mitochondria, and disruption and disorganization of microfilaments and microtubules [ 17].
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