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While there have been many advances in quartet puzzling over the past years (see [ 17, 20, 26] for example) we used the traditional puzzling algorithm to allow a more true comparison between invariant based puzzling and traditional maximum likelihood puzzling.
Significant strengths of this study design are related to the homogeneity of patient groups examined as well as the similarities between the two hospitals allowing a more true comparison between factors associated with hospital-specific practice differences without the usual confounders of differing patient characteristics or even geographic differences between hospitals and patients.
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While the extent to which this is the case is unknown, if undiagnosed abusers are more costly than a true comparison population comprising patients who are not abusers, this would imply that the estimated excess costs of diagnosed abuse understate the actual excess cost differential between abusers and a comparison population of patients without diagnosed or undiagnosed opioid abuse.
By comparison, although Mitchell et al. [24] general practitioners discovered more true cases of depression, they were more likely than not to misdiagnose healthy subjects as depressed.
In comparison to other tools, we find that Proteny finds clusters with more true homologies in fewer clusters that contain more genes, i.e. Proteny is able to identify a more consistent synteny.
The true comparison is not with 1969, but with 1939.
Rarely has that been more true.
That is even more true of cotton.
That advice has never been more true.
If anything, this seems more true today.
This is even more true today.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com