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Four more trials have been published since [ 2- 5].
Three more trials have been published since the publication of that review.
Since the previous Cochrane systematic review on the topic published in 2001, 11 12 many more trials have been published and an updated synthesis of the literature is needed.
The ATLAS (Adjuvant Tamoxifen: Longer Against Shorter) and aTTom (Adjuvant Tamoxifen: To Offer More?) trials have reported their findings, and results show that extended tamoxifen therapy (5 additional years) in women with early-stage breast cancer reduces the risk of late recurrences [ 6].
More trials have been identified in this review than in any previous systematic review, which can be partly explained by broader inclusion criteria: we included trials of all sizes in our review, did not restrict the review to English-language papers and included patients with type 1 diabetes.
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With Saddam now executed, and the insurgency still raging, enthusiasm among Iraqis and in the international community for yet more trials has waned.
Imbalance in one or more trials has no effect on standard meta-analysis.
Including more trials has allowed us to provide a more in-depth evaluation of the pharmacological treatments that have been tested for sciatica in primary care.
Also, the three most recent studies [ 7, 20, 22] were more sensitive at measuring differences than the earlier studies [ 21, 24], because results were based on more trials, had a larger age range, were analyzed per year group and step sizes were smaller.
Therefore, more and more clinical trials have been designed to treat patients with advanced NSCLC.
More recent trials have demonstrated the limits on empiric dose escalation and the benefits of optimized scheduling.
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CEO of Professional Science Editing for Scientists @ prosciediting.com