The Zika virus seemed a much more tractable target.
Towards that end, we believe that studying groups of patients with common patterns of disease is a useful concept and is a more tractable target in the short term than truly understanding individualized dynamics.
As a consequence, this will highlight the need to treat not only the tumour itself but also the SIR, a potentially more tractable target compared with well-established weight loss and/or poor performance status.
First, EWS ETS chimeras are challenging to drug, although potential downstream pathways may be more tractable for targeting (Braunreiter et al, 2006; Prieur et al, 2004; Smith et al, 2006).
The reawakening of interest in this target resulted from an improved understanding of the enzyme, making it a more tractable and attractive target.
An sRNA and its target may also be transformed into a more tractable genetic system, such as Nicotiana benthamiana, to test whether PTGS occurs in vivo.
When close homology to the target protein can be found in PDB, the problem becomes more tractable.
Targeting key host factors, on the other hand, may be a more tractable approach, as it should be more difficult for a virus to develop resistance.
However, RAS proteins themselves have so far proved impossible to inhibit selectively using drugs, so attention has shifted to targeting the downstream signaling pathways controlled by RAS, which contain several more tractable enzymes, such as RAF, MEK and AKT protein kinases and the lipid phosphoinositide (PI) 3-kinases.
However, in a bacterial genome as stable as M. tuberculosis an approach that specifically targets variable regions, such as insertion sites that can provide sufficient phylogenetic information, may still prove more tractable than full genome re-sequencing of strains.
As a romantic tenor, Zampa automatically appears in a more tractable, more civilized light.
