However, RAS proteins themselves have so far proved impossible to inhibit selectively using drugs, so attention has shifted to targeting the downstream signaling pathways controlled by RAS, which contain several more tractable enzymes, such as RAF, MEK and AKT protein kinases and the lipid phosphoinositide (PI) 3-kinases.
In trying to overcome this obstacle, thus to speed up SPRIT, Hill et al. propose a divide-and-conquer-type reduction that breaks the problem into several smaller and more tractable subproblems before calculating the rSPR distance for each subproblem separately.
Extending this same approach to other response variables that are now more tractable, such as restriction of gene flow in selected versus neutral loci, and comparison across several hybrid zones with different levels of divergence, will soon enable us to break from assumptions of what a "good" species should be, and directly illuminate the multidimensional nature of species formation.
Because primary cells are difficult to manipulate, several labs, including ours, have turned to established cell lines for use as a more tractable system for studying viral recognition and innate immune responses to infection.
His team is one of several industrial research groups recently formed or expanded thanks to growing signs that the technology behind quantum computing is becoming more tractable.
The Zika virus seemed a much more tractable target.
As a romantic tenor, Zampa automatically appears in a more tractable, more civilized light.
Numbers make problems less resonant emotionally but more tractable intellectually.
Goode found more tractable challenges at the Durrell Trust's Chelonian Captive Breeding Centre, in Ampijoroa.
It's not that autism and ADHD are somehow more tractable for researchers than other disorders.
