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Regulatory measures that make rapid approval of new drugs paramount sometimes have led to marketing of drugs with more toxicity than the public finds acceptable.
The combination of gemcitabine plus docetaxel resulted in more toxicity than doxorubicin alone.
In general terms, whole sediment bioassays have shown more toxicity than pore water tests.
Nanoparticles are more inclined to cellular internalization and show more toxicity than the larger ones [14, 15].
The active compounds namely, 1,4-NQ, 2,4-DNPS, 4-NBT and MD showed more toxicity than 3-DAP against the 3T3 cell line.
We introduced galactose with two types of chemical bonds; amide and amine, and the amine connection showed lower ingestion and more toxicity than the amide one.
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MDR values smaller than 1 indicate that the product is less and MDR values greater than 1 indicate that the product toxicity more toxic than predicted, respectively.
Only C12PB and C12BZK show slightly more toxicity to sperm than they do to polarized epithelial cells but even in these two cases their narrow therapeutic indices imply that their use as contraceptive agents should be implemented with great care.
Biofilms have been shown to be many times more resistant to antibiotics and more toxicity to host than planktonic or free-swimming cells so as to improve the possibility of metabolization and survival in the antibacterial conditions [ 23, 24].
Concerning toxicity aspects, due to smaller size, SWCNTs seem to be more toxic than MWCNTs, and toxicity is further increased by functionalization of nanotubes [125].
But the dihydroisocoumarins (1 3) showed more toxicity on A549 cell lines than that of Glycyrrhizic acid [7].
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CEO of Professional Science Editing for Scientists @ prosciediting.com